Assay Detail
Binding
CHEMBL4134216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta in 50% rat blood assessed as reduction in anti-IgM stimulated CD86 expression pretreated for 1 hr followed by anti-IgM stimulation after 24 hrs by flow cytometric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.21 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3643414 | — | — | 1 | 7.80 |
| CHEMBL3643407 | — | — | 1 | 7.24 |
| CHEMBL3947814 | — | — | 1 | 7.18 |
| CHEMBL3977066 | — | — | 1 | 7.14 |
| CHEMBL3643427 | — | — | 1 | 7.14 |
| CHEMBL3643429 | — | — | 1 | 7.13 |
| CHEMBL3643349 | — | — | 1 | 7.04 |
| CHEMBL3643413 | LENIOLISIB | 4.0 | 1 | 7.00 |
| CHEMBL4164149 | — | — | 1 | - |
| CHEMBL4163245 | — | — | 1 | - |
| CHEMBL4171158 | — | — | 1 | - |
| CHEMBL3643409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3643414 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3643407 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3947814 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3977066 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3643427 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3643429 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3643349 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3643413 | LENIOLISIB | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4164149 | — | IC50 | - | — | - | |
| CHEMBL4163245 | — | IC50 | - | — | - | |
| CHEMBL4171158 | — | IC50 | - | — | - | |
| CHEMBL3643409 | — | IC50 | - | — | - |