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Assay Detail

CHEMBL4134626

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Noncompetitive inhibition of human neutrophil elastase using varying levels of MeOSuc-AAPV-pNA as substrate measured after 30 mins by double-reciprocal Lineweaver-Burk plot analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neutrophil elastase (CHEMBL248)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potential Anti-inflammatory Effects of the Fruits of Paulownia tomentosa.
Ryu HW, Park YJ, Lee SU, Lee S, Yuk HJ, Seo KH, Kim YU, Hwang BY, Oh SR.
J Nat Prod (2017) 80 : 2659 -2665
PubMed 28968119 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 4.98 5.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4174694 1 5.50
CHEMBL253152 1 5.37
CHEMBL4160635 1 5.28
CHEMBL4167885 1 5.20
CHEMBL4171240 1 5.08
CHEMBL151 LUTEOLIN 2.0 1 5.00
CHEMBL499116 TANARIFLAVANONE D 1 4.93
CHEMBL50 QUERCETIN 3.0 1 4.92
CHEMBL4167043 1 4.91
CHEMBL2387711 1 4.90
CHEMBL4164709 1 4.88
CHEMBL223256 NYMPHAEOL A 1 4.80
CHEMBL4167477 1 4.71
CHEMBL28 APIGENIN 1 4.30
CHEMBL4175745 1 -
CHEMBL463842 1 -
CHEMBL2011404 1 -
CHEMBL4161293 1 -
CHEMBL2387712 1 -
CHEMBL4168536 1 -
CHEMBL2387714 1 -
CHEMBL2387715 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4174694 Ki = 3200.0 nM 5.50
CHEMBL253152 Ki = 4300.0 nM 5.37
CHEMBL4160635 Ki = 5300.0 nM 5.28
CHEMBL4167885 Ki = 6300.0 nM 5.20
CHEMBL4171240 Ki = 8300.0 nM 5.08
CHEMBL151 LUTEOLIN Ki = 10100.0 nM 5.00
CHEMBL499116 TANARIFLAVANONE D Ki = 11700.0 nM 4.93
CHEMBL50 QUERCETIN Ki = 11900.0 nM 4.92
CHEMBL4167043 Ki = 12400.0 nM 4.91
CHEMBL2387711 Ki = 12500.0 nM 4.90
CHEMBL4164709 Ki = 13100.0 nM 4.88
CHEMBL223256 NYMPHAEOL A Ki = 15700.0 nM 4.80
CHEMBL4167477 Ki = 19500.0 nM 4.71
CHEMBL28 APIGENIN Ki = 49900.0 nM 4.30
CHEMBL4175745 Ki - -
CHEMBL463842 Ki - -
CHEMBL2011404 Ki - -
CHEMBL4161293 Ki - -
CHEMBL2387712 Ki - -
CHEMBL4168536 Ki - -
CHEMBL2387714 Ki - -
CHEMBL2387715 Ki - -