Assay Detail
Functional
CHEMBL4134677
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Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.13 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173338 | — | — | 1 | 5.63 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.41 |
| CHEMBL4166084 | — | — | 1 | 5.39 |
| CHEMBL4169910 | — | — | 1 | 4.63 |
| CHEMBL4176702 | — | — | 1 | 4.57 |
| CHEMBL4162637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173338 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL4166084 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4169910 | — | IC50 | = | 23270.0 | nM | 4.63 |
| CHEMBL4176702 | — | IC50 | = | 26860.0 | nM | 4.57 |
| CHEMBL4162637 | — | IC50 | > | 32000.0 | nM | - |