Assay Detail
Binding
CHEMBL4134682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAOB (unknown origin) using beetle luciferin as substrate by MAO-Glo assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.54 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.03 |
| CHEMBL313833 | — | — | 1 | 5.53 |
| CHEMBL4173338 | — | — | 1 | 4.06 |
| CHEMBL4169910 | — | — | 1 | - |
| CHEMBL4162637 | — | — | 1 | - |
| CHEMBL4166084 | — | — | 1 | - |
| CHEMBL4176702 | — | — | 1 | - |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL313833 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4173338 | — | IC50 | = | 87090.0 | nM | 4.06 |
| CHEMBL4169910 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4162637 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4166084 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4176702 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL98 | VORINOSTAT | IC50 | > | 100000.0 | nM | - |