Assay Detail
Binding
CHEMBL4134684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged human HDAC1 expressed in baculovirus expression system using Ac-peptide substrate incubated for 15 mins by fluorescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.09 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166084 | — | — | 1 | 7.92 |
| CHEMBL4173338 | — | — | 1 | 7.82 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.80 |
| CHEMBL4162637 | — | — | 1 | 6.66 |
| CHEMBL4176702 | — | — | 1 | 6.50 |
| CHEMBL4169910 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166084 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4173338 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4162637 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4176702 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL4169910 | — | IC50 | = | 1436.0 | nM | 5.84 |