Assay Detail
Binding
CHEMBL4134685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal His-tagged full length human HDAC2 expressed in baculovirus expression system using Ac-peptide substrate incubated for 15 mins by fluorescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.83 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173338 | — | — | 1 | 7.64 |
| CHEMBL4166084 | — | — | 1 | 7.60 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.55 |
| CHEMBL4162637 | — | — | 1 | 6.38 |
| CHEMBL4176702 | — | — | 1 | 6.31 |
| CHEMBL4169910 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173338 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4166084 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4162637 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL4176702 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL4169910 | — | IC50 | = | 3103.0 | nM | 5.51 |