Assay Detail

CHEMBL4134917

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Binding

Inhibition of recombinant human sPLA2 using [1-14C]oleate-labelled autoclaved Escherichia coli as substrate measured after 15 mins

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels.

Starkus JG, Poerzgen P, Layugan K, Kawabata KG, Goto JI, Suzuki S, Myers G, Kelly M, Penner R, Fleig A, Horgen FD.
J Nat Prod (2017) 80 : 2741 -2750
PubMed 29019677 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.27	5.27

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL487005	SCALARADIAL	—	1	5.27

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL487005	SCALARADIAL	IC50	=	5400.0	nM	5.27