Assay Detail
Functional
CHEMBL4134978
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Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.23 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214827 | ONALESPIB | 2.0 | 1 | 7.50 |
| CHEMBL4172764 | — | — | 1 | 5.92 |
| CHEMBL4162087 | — | — | 1 | 5.89 |
| CHEMBL4174241 | — | — | 1 | 5.86 |
| CHEMBL4167160 | — | — | 1 | 5.85 |
| CHEMBL4168297 | — | — | 1 | 5.82 |
| CHEMBL4169329 | — | — | 1 | 5.77 |
| CHEMBL4164129 | — | — | 1 | 5.77 |
| CHEMBL4167571 | — | — | 1 | 5.60 |
| CHEMBL4159246 | — | — | 1 | 5.59 |
| CHEMBL4168492 | — | — | 1 | 5.53 |
| CHEMBL4160586 | — | — | 1 | 5.52 |
| CHEMBL4176933 | — | — | 1 | 5.51 |
| CHEMBL547269 | — | — | 1 | 5.44 |
| CHEMBL528807 | — | — | 1 | 5.42 |
| CHEMBL4169369 | — | — | 1 | 5.39 |
| CHEMBL1313955 | — | — | 1 | 5.34 |
| CHEMBL527677 | — | — | 1 | 5.31 |
| CHEMBL4165529 | — | — | 1 | 5.28 |
| CHEMBL4163544 | — | — | 1 | 5.28 |
| CHEMBL4168343 | — | — | 1 | 5.27 |
| CHEMBL4161029 | — | — | 1 | 5.23 |
| CHEMBL4160183 | — | — | 1 | 5.21 |
| CHEMBL4159891 | — | — | 1 | 5.17 |
| CHEMBL4163977 | — | — | 1 | 5.15 |
| CHEMBL194184 | — | — | 1 | 5.11 |
| CHEMBL4167138 | — | — | 1 | 5.11 |
| CHEMBL4162935 | — | — | 1 | 5.08 |
| CHEMBL4161445 | — | — | 1 | 5.05 |
| CHEMBL4175015 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214827 | ONALESPIB | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4172764 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4162087 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4174241 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4167160 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4168297 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4169329 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4164129 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4167571 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL4159246 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL4168492 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4160586 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4176933 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL547269 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL528807 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL4169369 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL1313955 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL527677 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL4165529 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4163544 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4168343 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL4161029 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL4160183 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL4159891 | — | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL4163977 | — | IC50 | = | 7060.0 | nM | 5.15 |
| CHEMBL194184 | — | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL4167138 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4162935 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL4161445 | — | IC50 | = | 8920.0 | nM | 5.05 |
| CHEMBL4175015 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4171635 | — | IC50 | = | 11640.0 | nM | 4.93 |
| CHEMBL4160339 | — | IC50 | = | 11950.0 | nM | 4.92 |
| CHEMBL4166701 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4173970 | — | IC50 | = | 14190.0 | nM | 4.85 |
| CHEMBL4175299 | — | IC50 | = | 14720.0 | nM | 4.83 |
| CHEMBL4170535 | — | IC50 | = | 15840.0 | nM | 4.80 |
| CHEMBL4168644 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL4167422 | — | IC50 | = | 26560.0 | nM | 4.58 |
| CHEMBL4176140 | — | IC50 | = | 27520.0 | nM | 4.56 |
| CHEMBL4170946 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL1302317 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL4171998 | — | IC50 | = | 33340.0 | nM | 4.48 |
| CHEMBL4170817 | — | IC50 | = | 41190.0 | nM | 4.38 |
| CHEMBL4175442 | — | IC50 | = | 48610.0 | nM | 4.31 |
| CHEMBL4160727 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4164860 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1388745 | — | IC50 | > | 50000.0 | nM | - |