Assay Detail
Functional
CHEMBL4135099
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Cytotoxic activity in human Colo-357 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO357 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.96 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4176275 | — | — | 1 | 9.52 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.89 |
| CHEMBL4159771 | — | — | 1 | 8.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4176275 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4159771 | — | IC50 | = | 3.5 | nM | 8.46 |