Assay Detail
Binding
CHEMBL4135370
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Inhibition of human COX-2 using [14C]-arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by thin layer chromatographic method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.21 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4169347 | — | — | 1 | 6.64 |
| CHEMBL4173526 | — | — | 1 | 6.55 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.52 |
| CHEMBL4177185 | — | — | 1 | 6.47 |
| CHEMBL4162061 | — | — | 1 | 6.24 |
| CHEMBL4172740 | — | — | 1 | 6.10 |
| CHEMBL4165597 | — | — | 1 | 6.09 |
| CHEMBL4176892 | — | — | 1 | 6.06 |
| CHEMBL4169030 | — | — | 1 | 6.04 |
| CHEMBL4161755 | — | — | 1 | 6.01 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4169347 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4173526 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL118 | CELECOXIB | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4177185 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4162061 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4172740 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4165597 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4176892 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4169030 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4161755 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 2630.0 | nM | 5.58 |