Assay Detail
Binding
CHEMBL4135375
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Inhibition of dog kidney microsomal COX assessed as PGE2 level using arachidonic acid as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 40 mins by radio immunoassay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Kidney |
| Subcellular | Microsomal |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.25 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4169347 | — | — | 1 | 7.47 |
| CHEMBL4173526 | — | — | 1 | 7.41 |
| CHEMBL4177185 | — | — | 1 | 7.40 |
| CHEMBL4162061 | — | — | 1 | 7.35 |
| CHEMBL4172740 | — | — | 1 | 7.28 |
| CHEMBL4165597 | — | — | 1 | 7.25 |
| CHEMBL4176892 | — | — | 1 | 7.21 |
| CHEMBL4169030 | — | — | 1 | 7.11 |
| CHEMBL4161755 | — | — | 1 | 7.10 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4169347 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4173526 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4177185 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4162061 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4172740 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4165597 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4176892 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4169030 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4161755 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL118 | CELECOXIB | IC50 | = | 112.0 | nM | 6.95 |