Assay Detail
Functional
CHEMBL4135405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells after 24 to 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and Structure-Activity Relationship of angiotensin-converting enzyme inhibitors with cardiovascular regulation and thrombolytic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.99 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4174467 | — | — | 1 | 7.09 |
| CHEMBL4160421 | — | — | 1 | 7.04 |
| CHEMBL4163792 | — | — | 1 | 6.99 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4174467 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4160421 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4163792 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 142.0 | nM | 6.85 |