Assay Detail
Functional
CHEMBL4135514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A498 cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A498 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.89 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161911 | — | — | 1 | 8.47 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.10 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 5.07 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161911 | — | IC50 | = | 3.35 | nM | 8.47 |
| CHEMBL535 | SUNITINIB | IC50 | = | 7981.0 | nM | 5.10 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 8456.0 | nM | 5.07 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 12500.0 | nM | 4.90 |