Assay Detail
Functional
CHEMBL4135516
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Antiproliferative activity against human NCI-H727 cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H727 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.15 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161911 | — | — | 1 | 8.59 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.00 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 4.85 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161911 | — | IC50 | = | 2.55 | nM | 8.59 |
| CHEMBL535 | SUNITINIB | IC50 | = | 10120.0 | nM | 5.00 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 14010.0 | nM | 4.85 |
| CHEMBL553 | ERLOTINIB | IC50 | > | 6240.0 | nM | - |