Assay Detail
Binding
CHEMBL4135584
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluorescence assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 2 (CHEMBL5014) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.49 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4176853 | — | — | 1 | 8.70 |
| CHEMBL4161327 | — | — | 1 | 8.52 |
| CHEMBL4171924 | — | — | 1 | 8.52 |
| CHEMBL4173493 | — | — | 1 | 8.30 |
| CHEMBL4161723 | — | — | 1 | 8.30 |
| CHEMBL4160817 | — | — | 1 | 8.30 |
| CHEMBL4166239 | — | — | 1 | 8.22 |
| CHEMBL4159424 | — | — | 1 | 8.15 |
| CHEMBL4170048 | — | — | 1 | 8.15 |
| CHEMBL4162788 | — | — | 1 | 8.10 |
| CHEMBL4164217 | — | — | 1 | 8.05 |
| CHEMBL4168738 | — | — | 1 | 7.96 |
| CHEMBL4163484 | — | — | 1 | 7.80 |
| CHEMBL4167668 | — | — | 1 | 7.70 |
| CHEMBL4171039 | — | — | 1 | 7.68 |
| CHEMBL4162913 | — | — | 1 | 7.62 |
| CHEMBL4173646 | — | — | 1 | 7.54 |
| CHEMBL4174187 | — | — | 1 | 7.46 |
| CHEMBL4170854 | — | — | 1 | 7.42 |
| CHEMBL4160116 | — | — | 1 | 7.40 |
| CHEMBL4172092 | — | — | 1 | 7.35 |
| CHEMBL4169652 | — | — | 1 | 7.24 |
| CHEMBL4165728 | — | — | 1 | 7.22 |
| CHEMBL4165019 | — | — | 1 | 7.16 |
| CHEMBL4166371 | — | — | 1 | 7.05 |
| CHEMBL4160433 | — | — | 1 | 6.92 |
| CHEMBL4167365 | — | — | 1 | 6.89 |
| CHEMBL4166930 | — | — | 1 | 6.80 |
| CHEMBL4175635 | — | — | 1 | 6.75 |
| CHEMBL4175533 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4176853 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4161327 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4171924 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4173493 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4161723 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4160817 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4166239 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4159424 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4170048 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4162788 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4164217 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4168738 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4163484 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4167668 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4171039 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4162913 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4173646 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4174187 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4170854 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4160116 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4172092 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4169652 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4165728 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4165019 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4166371 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4160433 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4167365 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4166930 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4175635 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4175533 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4159032 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4170760 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4164029 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1078785 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4174288 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4175235 | — | IC50 | > | 10000.0 | nM | - |