Assay Detail
Binding
CHEMBL4135614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RIPK2 in C57BL/6 mouse BMDM assessed as reduction in MDP/LPS-stimulated IL6 secretion pretreated for 30 mins followed by MDP/LPS stimulation after 18 hrs
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BMDM |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Receptor-interacting serine/threonine-protein kinase 2 (CHEMBL4296021) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 2 | 8.07 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173493 | — | — | 2 | 8.22 |
| CHEMBL4161327 | — | — | 2 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173493 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4161327 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4173493 | — | Inhibition | - | % | - | |
| CHEMBL4161327 | — | Inhibition | - | % | - |