Assay Detail
Binding
CHEMBL4135736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM1 (unknown origin) using TAMRA-ERMRPRKRQGSVRRRV-NH2 as substrate pretreated for 30 mins followed by substrate addition measured after 1 hr by IMAP assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.78 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161596 | — | — | 1 | 6.90 |
| CHEMBL4172211 | — | — | 1 | 6.50 |
| CHEMBL260163 | — | — | 1 | 6.30 |
| CHEMBL4174177 | — | — | 1 | 5.70 |
| CHEMBL4176717 | — | — | 1 | 5.60 |
| CHEMBL4165288 | — | — | 1 | 5.60 |
| CHEMBL4163479 | — | — | 1 | 4.80 |
| CHEMBL4168859 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161596 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4172211 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL260163 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4174177 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4176717 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4165288 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4163479 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL4168859 | — | IC50 | = | 15848.93 | nM | 4.80 |