Assay Detail
Binding
CHEMBL4135737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GSK3beta (unknown origin) after 1 hr by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.71 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260163 | — | — | 1 | 7.00 |
| CHEMBL4172211 | — | — | 1 | 6.20 |
| CHEMBL4176717 | — | — | 1 | 5.90 |
| CHEMBL4174177 | — | — | 1 | 5.80 |
| CHEMBL4165288 | — | — | 1 | 5.50 |
| CHEMBL4163479 | — | — | 1 | 5.10 |
| CHEMBL4168859 | — | — | 1 | 4.50 |
| CHEMBL4175904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260163 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4172211 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4176717 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4174177 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4165288 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4163479 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4168859 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL4175904 | — | IC50 | > | 25118.86 | nM | - |