Assay Detail
Binding
CHEMBL4136264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.82 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171244 | — | — | 1 | 9.02 |
| CHEMBL4170680 | — | — | 1 | 8.85 |
| CHEMBL502835 | NINTEDANIB | 4.0 | 1 | 8.59 |
| CHEMBL4168811 | — | — | 1 | - |
| CHEMBL4161551 | — | — | 1 | - |
| CHEMBL4172155 | — | — | 1 | - |
| CHEMBL4165455 | — | — | 1 | - |
| CHEMBL4173370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171244 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL4170680 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL502835 | NINTEDANIB | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4168811 | — | IC50 | > | 30.0 | nM | - |
| CHEMBL4161551 | — | IC50 | > | 30.0 | nM | - |
| CHEMBL4172155 | — | IC50 | > | 30.0 | nM | - |
| CHEMBL4165455 | — | IC50 | > | 30.0 | nM | - |
| CHEMBL4173370 | — | IC50 | > | 30.0 | nM | - |