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Assay Detail

CHEMBL4136404

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Malassezia globosa beta-carbonic anhydrase incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Malassezia globosa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study.
Nocentini A, Cadoni R, Del Prete S, Capasso C, Dumy P, Gratteri P, Supuran CT, Winum JY.
ACS Med Chem Lett (2017) 8 : 1194 -1198
PubMed 29152053 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 4.39 5.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4167691 1 5.27
CHEMBL4166184 1 5.21
CHEMBL4159776 1 5.06
CHEMBL4176682 1 4.67
CHEMBL4166580 1 4.65
CHEMBL4174497 1 4.60
CHEMBL4164241 1 4.54
CHEMBL4173293 1 4.52
CHEMBL4174896 1 4.51
CHEMBL4167266 1 4.35
CHEMBL4166065 1 4.30
CHEMBL4166821 1 4.25
CHEMBL4160012 1 4.24
CHEMBL4171057 1 4.21
CHEMBL4163368 1 4.20
CHEMBL4163139 1 4.15
CHEMBL4161495 1 4.13
CHEMBL20 ACETAZOLAMIDE 4.0 1 4.12
CHEMBL4177136 1 4.12
CHEMBL4174083 1 4.11
CHEMBL4170654 1 4.06
CHEMBL4175131 1 4.04
CHEMBL4172094 1 4.01
CHEMBL443052 TAVABOROLE 4.0 1 4.00
CHEMBL378506 BENZOXABOROLE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4167691 Ki = 5346.0 nM 5.27
CHEMBL4166184 Ki = 6095.0 nM 5.21
CHEMBL4159776 Ki = 8675.0 nM 5.06
CHEMBL4176682 Ki = 21319.0 nM 4.67
CHEMBL4166580 Ki = 22531.0 nM 4.65
CHEMBL4174497 Ki = 24906.0 nM 4.60
CHEMBL4164241 Ki = 28765.0 nM 4.54
CHEMBL4173293 Ki = 30100.0 nM 4.52
CHEMBL4174896 Ki = 30625.0 nM 4.51
CHEMBL4167266 Ki = 44603.0 nM 4.35
CHEMBL4166065 Ki = 49762.0 nM 4.30
CHEMBL4166821 Ki = 55637.0 nM 4.25
CHEMBL4160012 Ki = 58214.0 nM 4.24
CHEMBL4171057 Ki = 62187.0 nM 4.21
CHEMBL4163368 Ki = 63687.0 nM 4.20
CHEMBL4163139 Ki = 71221.0 nM 4.15
CHEMBL4161495 Ki = 73614.0 nM 4.13
CHEMBL20 ACETAZOLAMIDE Ki = 76000.0 nM 4.12
CHEMBL4177136 Ki = 76193.0 nM 4.12
CHEMBL4174083 Ki = 77855.0 nM 4.11
CHEMBL4170654 Ki = 86833.0 nM 4.06
CHEMBL4175131 Ki = 91276.0 nM 4.04
CHEMBL4172094 Ki = 98557.0 nM 4.01
CHEMBL443052 TAVABOROLE Ki = 99022.0 nM 4.00
CHEMBL378506 BENZOXABOROLE Ki = 109130.0 nM -