Assay Detail
Functional
CHEMBL4136429
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Cytotoxicity in human NCI-H157 cells assessed as reduction in cell viability after 4 days under dark condition by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H157 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Photoresponsive azo-combretastatin A-4 analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.18 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.00 |
| CHEMBL4173242 | — | — | 1 | 5.00 |
| CHEMBL4160439 | — | — | 1 | 5.00 |
| CHEMBL4161895 | — | — | 1 | 4.75 |
| CHEMBL4165093 | — | — | 1 | 4.30 |
| CHEMBL4166392 | — | — | 1 | 4.05 |
| CHEMBL4165329 | — | — | 1 | - |
| CHEMBL4176606 | — | — | 1 | - |
| CHEMBL4168744 | — | — | 1 | - |
| CHEMBL4177012 | — | — | 1 | - |
| CHEMBL4169817 | — | — | 1 | - |
| CHEMBL4168347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4173242 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4160439 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4161895 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4165093 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4166392 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL4165329 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4176606 | — | IC50 | - | — | - | |
| CHEMBL4168744 | — | IC50 | - | — | - | |
| CHEMBL4177012 | — | IC50 | - | — | - | |
| CHEMBL4169817 | — | IC50 | - | — | - | |
| CHEMBL4168347 | — | IC50 | - | — | - |