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Assay Detail

CHEMBL4136430

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NCI-H157 cells assessed as reduction in cell viability irradiated with 400 nanometer UV light for 10 secs every 34 mins for 4 days by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H157
Confidence 1 — Organism
Curated By Intermediate

Target

NCI-H157 (CHEMBL614783)
Type CELL-LINE
Organism Homo sapiens

Publication

Photoresponsive azo-combretastatin A-4 analogues.
Rastogi SK, Zhao Z, Barrett SL, Shelton SD, Zafferani M, Anderson HE, Blumenthal MO, Jones LR, Wang L, Li X, Streu CN, Du L, Brittain WJ.
Eur J Med Chem (2018) 143 : 1 -7
PubMed 29172077 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.66 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4165093 1 6.80
CHEMBL4165329 1 6.70
CHEMBL4173242 1 5.72
CHEMBL4176606 1 5.70
CHEMBL4160439 1 5.44
CHEMBL4161895 1 5.28
CHEMBL4166392 1 4.00
CHEMBL4168744 1 -
CHEMBL4177012 1 -
CHEMBL4169817 1 -
CHEMBL4168347 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4165093 IC50 = 160.0 nM 6.80
CHEMBL4165329 IC50 = 200.0 nM 6.70
CHEMBL4173242 IC50 = 1900.0 nM 5.72
CHEMBL4176606 IC50 = 2000.0 nM 5.70
CHEMBL4160439 IC50 = 3600.0 nM 5.44
CHEMBL4161895 IC50 = 5300.0 nM 5.28
CHEMBL4166392 IC50 = 100000.0 nM 4.00
CHEMBL4168744 IC50 - -
CHEMBL4177012 IC50 - -
CHEMBL4169817 IC50 - -
CHEMBL4168347 IC50 - -