Assay Detail
Functional
CHEMBL4136581
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by DAPI staining based confocal microplate imaging method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.22 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 9.52 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.00 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 8.22 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 7.92 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.64 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.28 |
| CHEMBL4163038 | — | — | 1 | 6.51 |
| CHEMBL4165417 | — | — | 1 | 6.29 |
| CHEMBL4173741 | — | — | 1 | 6.17 |
| CHEMBL4177103 | — | — | 1 | 5.47 |
| CHEMBL4173331 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4163038 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4165417 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4173741 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4177103 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4173331 | — | IC50 | = | 3600.0 | nM | 5.44 |