Assay Detail
Binding
CHEMBL4136597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His6-tagged USP28-5 (1 to 1077 residues) using Ub-Rh110 as substrate pretreated for 30 mins followed by substrate addition measured after 20 mins by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Ubiquitin-Specific Inhibitors for the Treatment of Cancers, Autoimmune, and Infectious Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.70 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166283 | — | — | 1 | 6.70 |
| CHEMBL4160957 | — | — | 1 | 6.70 |
| CHEMBL4176483 | — | — | 1 | 6.70 |
| CHEMBL4162425 | — | — | 1 | 6.70 |
| CHEMBL4159041 | — | — | 1 | 6.70 |
| CHEMBL4173102 | — | — | 1 | - |
| CHEMBL4169696 | — | — | 1 | - |
| CHEMBL4174196 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166283 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4160957 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4176483 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4162425 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4159041 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4173102 | — | IC50 | < | 200.0 | nM | - |
| CHEMBL4169696 | — | IC50 | < | 200.0 | nM | - |
| CHEMBL4174196 | — | IC50 | < | 200.0 | nM | - |