Assay Detail
ADMET
CHEMBL4136607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GSK3beta (unknown origin) using HSSPHQ(Sp)EDEEE as substrate by pyruvate kinase-lactate dehydrogenase coupled assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.31 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4174082 | — | — | 1 | 8.05 |
| CHEMBL4166840 | — | — | 1 | 7.16 |
| CHEMBL4167265 | — | — | 1 | 6.72 |
| CHEMBL4173877 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4174082 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4166840 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL4167265 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4173877 | — | Ki | > | 4000.0 | nM | - |