Assay Detail
Binding
CHEMBL4136616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cystathionine gamma-lyase (unknown origin) assessed as reduction in cysteine formation from CPM using L-cystathionine pre-incubated for 15 min followed by L-cystathionine and CPM addition and measured after 7 mins by fluorescence-based primary assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine γ-Lyase (CSE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.22 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163832 | — | — | 1 | 5.92 |
| CHEMBL4159854 | — | — | 1 | 5.72 |
| CHEMBL4166278 | — | — | 1 | 5.70 |
| CHEMBL4160453 | — | — | 1 | 5.70 |
| CHEMBL4171052 | — | — | 1 | 5.70 |
| CHEMBL4162824 | — | — | 1 | 5.70 |
| CHEMBL4168463 | — | — | 1 | 5.68 |
| CHEMBL4167775 | — | — | 1 | 5.60 |
| CHEMBL4166122 | — | — | 1 | 5.57 |
| CHEMBL4169541 | — | — | 1 | 5.52 |
| CHEMBL4176894 | — | — | 1 | 5.52 |
| CHEMBL4170080 | — | — | 1 | 5.46 |
| CHEMBL4170257 | — | — | 1 | 5.30 |
| CHEMBL4177072 | — | — | 1 | 5.30 |
| CHEMBL4173530 | — | — | 1 | 5.22 |
| CHEMBL4160479 | — | — | 1 | 5.22 |
| CHEMBL4159631 | — | — | 1 | 5.22 |
| CHEMBL3318351 | — | — | 1 | 5.22 |
| CHEMBL4176749 | — | — | 1 | 5.22 |
| CHEMBL4174491 | — | — | 1 | 5.22 |
| CHEMBL4159463 | — | — | 1 | 5.22 |
| CHEMBL4169868 | — | — | 1 | 5.22 |
| CHEMBL4162997 | — | — | 1 | 5.16 |
| CHEMBL4161944 | — | — | 1 | 5.00 |
| CHEMBL4167285 | — | — | 1 | 5.00 |
| CHEMBL4174098 | — | — | 1 | 4.92 |
| CHEMBL4166444 | — | — | 1 | 4.92 |
| CHEMBL4159363 | — | — | 1 | 4.82 |
| CHEMBL4172146 | — | — | 1 | 4.82 |
| CHEMBL4173702 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163832 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4159854 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4166278 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4160453 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4171052 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4162824 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4168463 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4167775 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4166122 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4169541 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4176894 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4170080 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4170257 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4177072 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4173530 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4159631 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3318351 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4176749 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4159463 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4160479 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4169868 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4174491 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4162997 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4161944 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4167285 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4174098 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4166444 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4173702 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4172146 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4159363 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4162734 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4166176 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4175580 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4167710 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4170671 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4160038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4161625 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL73007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3199120 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4174582 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4166666 | — | IC50 | > | 100000.0 | nM | - |