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Assay Detail

CHEMBL4136792

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against drug-sensitive blood stage Plasmodium falciparum 3D7 by SYBR green 1 staining based fluorescence assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.
Parra LLL, Bertonha AF, Severo IRM, Aguiar ACC, de Souza GE, Oliva G, Guido RVC, Grazzia N, Costa TR, Miguel DC, Gadelha FR, Ferreira AG, Hajdu E, Romo D, Berlinck RGS.
J Nat Prod (2018) 81 : 188 -202
PubMed 29297684 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.51 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL361497 ARTESUNATE 4.0 1 8.40
CHEMBL747 CYCLOGUANIL 2.0 1 8.00
CHEMBL76 CHLOROQUINE 4.0 1 7.89
CHEMBL36 PYRIMETHAMINE 4.0 1 7.52
CHEMBL439783 1 6.00
CHEMBL4176096 1 5.70
CHEMBL4165487 1 5.52
CHEMBL4163163 1 5.52
CHEMBL4166159 1 5.40
CHEMBL109490 1 5.16
CHEMBL4161663 1 -
CHEMBL4176783 1 -
CHEMBL4162718 1 -
CHEMBL4173427 1 -
CHEMBL4172717 1 -
CHEMBL4162039 1 -
CHEMBL4164381 1 -
CHEMBL4160976 1 -
CHEMBL4171179 1 -
CHEMBL4160575 1 -
CHEMBL4174913 1 -
CHEMBL4167031 1 -
CHEMBL4159799 1 -
CHEMBL4170444 1 -
CHEMBL4173875 1 -
CHEMBL4168904 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL361497 ARTESUNATE IC50 = 4.0 nM 8.40
CHEMBL747 CYCLOGUANIL IC50 = 10.0 nM 8.00
CHEMBL76 CHLOROQUINE IC50 = 13.0 nM 7.89
CHEMBL36 PYRIMETHAMINE IC50 = 30.0 nM 7.52
CHEMBL439783 IC50 = 1000.0 nM 6.00
CHEMBL4176096 IC50 = 2000.0 nM 5.70
CHEMBL4165487 IC50 = 3000.0 nM 5.52
CHEMBL4163163 IC50 = 3000.0 nM 5.52
CHEMBL4166159 IC50 = 4000.0 nM 5.40
CHEMBL109490 IC50 = 7000.0 nM 5.16
CHEMBL4161663 IC50 > 10000.0 nM -
CHEMBL4176783 IC50 > 10000.0 nM -
CHEMBL4162718 IC50 > 10000.0 nM -
CHEMBL4173427 IC50 > 10000.0 nM -
CHEMBL4172717 IC50 > 10000.0 nM -
CHEMBL4162039 IC50 > 10000.0 nM -
CHEMBL4164381 IC50 > 10000.0 nM -
CHEMBL4160976 IC50 > 10000.0 nM -
CHEMBL4171179 IC50 > 10000.0 nM -
CHEMBL4160575 IC50 > 10000.0 nM -
CHEMBL4174913 IC50 > 10000.0 nM -
CHEMBL4167031 IC50 > 10000.0 nM -
CHEMBL4159799 IC50 > 10000.0 nM -
CHEMBL4170444 IC50 > 10000.0 nM -
CHEMBL4173875 IC50 > 10000.0 nM -
CHEMBL4168904 IC50 > 10000.0 nM -