Assay Detail
Functional
CHEMBL4136794
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine/cycloguanil/pyrimethamine-resistant blood stage Plasmodium falciparum K1 by SYBR green 1 staining based fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.59 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.52 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.78 |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | 6.27 |
| CHEMBL439783 | — | — | 1 | 5.96 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL747 | CYCLOGUANIL | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL439783 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 3900.0 | nM | 5.41 |