Assay Detail
Functional
CHEMBL4136885
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 by pico-green dye based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.60 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.20 |
| CHEMBL4170041 | — | — | 1 | 5.85 |
| CHEMBL4161838 | — | — | 1 | 5.64 |
| CHEMBL4166627 | — | — | 1 | 5.58 |
| CHEMBL4162116 | — | — | 1 | 5.24 |
| CHEMBL4166340 | — | — | 1 | 5.01 |
| CHEMBL4169757 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4170041 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4161838 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4166627 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4162116 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4166340 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4169757 | — | IC50 | = | 20000.0 | nM | 4.70 |