Assay Detail
Functional
CHEMBL4137388
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Immunosuppressive activity against human PBMC assessed as inhibition of PHA-stimulated cell proliferation preincubated for 2 hrs followed by PHA stimulation for 72 hrs by Hoechst 33258 dye-based fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.47 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173846 | — | — | 1 | 6.11 |
| CHEMBL4165923 | — | — | 1 | 6.11 |
| CHEMBL4165815 | — | — | 1 | 6.08 |
| CHEMBL4177202 | — | — | 1 | 5.97 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 5.43 |
| CHEMBL4167855 | — | — | 1 | 4.45 |
| CHEMBL4175712 | — | — | 1 | 4.16 |
| CHEMBL4169359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173846 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4165923 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4165815 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4177202 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL4167855 | — | IC50 | = | 35260.0 | nM | 4.45 |
| CHEMBL4175712 | — | IC50 | = | 69250.0 | nM | 4.16 |
| CHEMBL4169359 | — | IC50 | - | — | - |