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Assay Detail

CHEMBL4137414

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Functional
Antiproliferative activity against human MCF7 cells by MTT assay
ChEMBL ↗
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Intermediate

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).
Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE.
J Med Chem (2018) 61 : 6163 -6177
PubMed 29953808 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 62 6.67 7.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4163207 — — 1 7.32
CHEMBL4172538 — — 1 7.31
CHEMBL4162106 — — 1 7.19
CHEMBL4166651 — — 1 7.16
CHEMBL4161888 — — 1 7.15
CHEMBL4174905 — — 1 7.12
CHEMBL4172300 — — 1 7.10
CHEMBL4165321 — — 1 7.06
CHEMBL4167081 — — 1 7.05
CHEMBL4174224 — — 1 7.05
CHEMBL4175944 — — 1 7.03
CHEMBL4172041 — — 1 7.01
CHEMBL4168736 — — 1 7.00
CHEMBL4160814 — — 1 6.96
CHEMBL4161443 — — 1 6.92
CHEMBL4161659 — — 1 6.89
CHEMBL4161398 — — 1 6.89
CHEMBL4164147 — — 1 6.89
CHEMBL4174474 — — 1 6.89
CHEMBL4175370 — — 1 6.82
CHEMBL4164859 — — 1 6.80
CHEMBL4172969 — — 1 6.80
CHEMBL4163742 — — 1 6.80
CHEMBL4177279 — — 1 6.80
CHEMBL4171217 — — 1 6.80
CHEMBL4176924 — — 1 6.77
CHEMBL4176354 — — 1 6.77
CHEMBL4166694 — — 1 6.72
CHEMBL4168497 — — 1 6.72
CHEMBL4171859 — — 1 6.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4163207 — IC50 = 48.0 nM 7.32
CHEMBL4172538 — IC50 = 49.0 nM 7.31
CHEMBL4162106 — IC50 = 64.0 nM 7.19
CHEMBL4166651 — IC50 = 70.0 nM 7.16
CHEMBL4161888 — IC50 = 71.0 nM 7.15
CHEMBL4174905 — IC50 = 76.0 nM 7.12
CHEMBL4172300 — IC50 = 80.0 nM 7.10
CHEMBL4165321 — IC50 = 88.0 nM 7.06
CHEMBL4167081 — IC50 = 89.0 nM 7.05
CHEMBL4174224 — IC50 = 90.0 nM 7.05
CHEMBL4175944 — IC50 = 93.0 nM 7.03
CHEMBL4172041 — IC50 = 98.0 nM 7.01
CHEMBL4168736 — IC50 = 100.0 nM 7.00
CHEMBL4160814 — IC50 = 110.0 nM 6.96
CHEMBL4161443 — IC50 = 120.0 nM 6.92
CHEMBL4161659 — IC50 = 130.0 nM 6.89
CHEMBL4174474 — IC50 = 130.0 nM 6.89
CHEMBL4164147 — IC50 = 130.0 nM 6.89
CHEMBL4161398 — IC50 = 130.0 nM 6.89
CHEMBL4175370 — IC50 = 150.0 nM 6.82
CHEMBL4164859 — IC50 = 160.0 nM 6.80
CHEMBL4172969 — IC50 = 160.0 nM 6.80
CHEMBL4163742 — IC50 = 160.0 nM 6.80
CHEMBL4177279 — IC50 = 160.0 nM 6.80
CHEMBL4171217 — IC50 = 160.0 nM 6.80
CHEMBL4176924 — IC50 = 170.0 nM 6.77
CHEMBL4176354 — IC50 = 170.0 nM 6.77
CHEMBL4166694 — IC50 = 190.0 nM 6.72
CHEMBL4168497 — IC50 = 190.0 nM 6.72
CHEMBL4171859 — IC50 = 190.0 nM 6.72
CHEMBL4160602 — IC50 = 210.0 nM 6.68
CHEMBL4176553 — IC50 = 210.0 nM 6.68
CHEMBL4169584 — IC50 = 220.0 nM 6.66
CHEMBL4168941 — IC50 = 250.0 nM 6.60
CHEMBL4175716 — IC50 = 260.0 nM 6.58
CHEMBL4174608 — IC50 = 260.0 nM 6.58
CHEMBL4164054 — IC50 = 270.0 nM 6.57
CHEMBL4161015 — IC50 = 290.0 nM 6.54
CHEMBL4166308 — IC50 = 330.0 nM 6.48
CHEMBL4173103 — IC50 = 370.0 nM 6.43
CHEMBL4161250 — IC50 = 400.0 nM 6.40
CHEMBL4167859 — IC50 = 400.0 nM 6.40
CHEMBL4168573 — IC50 = 440.0 nM 6.36
CHEMBL4170108 — IC50 = 480.0 nM 6.32
CHEMBL4175490 — IC50 = 520.0 nM 6.28
CHEMBL4161724 — IC50 = 530.0 nM 6.28
CHEMBL4159489 — IC50 = 610.0 nM 6.21
CHEMBL4173564 — IC50 = 660.0 nM 6.18
CHEMBL3091939 — IC50 = 710.0 nM 6.15
CHEMBL4165282 — IC50 = 730.0 nM 6.14