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Assay Detail

CHEMBL4137415

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Functional
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
ChEMBL ↗
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Intermediate

Target

MDA-MB-231 (CHEMBL400) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).
Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE.
J Med Chem (2018) 61 : 6163 -6177
PubMed 29953808 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 62 6.62 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4163207 — — 1 7.48
CHEMBL4172538 — — 1 7.34
CHEMBL4166651 — — 1 7.28
CHEMBL4165321 — — 1 7.27
CHEMBL4174905 — — 1 7.21
CHEMBL4162106 — — 1 7.11
CHEMBL4160602 — — 1 7.11
CHEMBL4172041 — — 1 7.10
CHEMBL4161888 — — 1 7.09
CHEMBL4176924 — — 1 7.00
CHEMBL4175944 — — 1 7.00
CHEMBL4160814 — — 1 7.00
CHEMBL4164054 — — 1 6.96
CHEMBL4165282 — — 1 6.96
CHEMBL4161250 — — 1 6.92
CHEMBL4164147 — — 1 6.92
CHEMBL4169584 — — 1 6.92
CHEMBL4176553 — — 1 6.92
CHEMBL4173185 — — 1 6.89
CHEMBL4175370 — — 1 6.89
CHEMBL4161398 — — 1 6.89
CHEMBL4172300 — — 1 6.85
CHEMBL4171217 — — 1 6.82
CHEMBL4174474 — — 1 6.80
CHEMBL4172969 — — 1 6.80
CHEMBL4161659 — — 1 6.80
CHEMBL4177279 — — 1 6.80
CHEMBL4176354 — — 1 6.77
CHEMBL4168736 — — 1 6.75
CHEMBL4166694 — — 1 6.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4163207 — IC50 = 33.0 nM 7.48
CHEMBL4172538 — IC50 = 46.0 nM 7.34
CHEMBL4166651 — IC50 = 53.0 nM 7.28
CHEMBL4165321 — IC50 = 54.0 nM 7.27
CHEMBL4174905 — IC50 = 62.0 nM 7.21
CHEMBL4162106 — IC50 = 77.0 nM 7.11
CHEMBL4160602 — IC50 = 78.0 nM 7.11
CHEMBL4172041 — IC50 = 80.0 nM 7.10
CHEMBL4161888 — IC50 = 82.0 nM 7.09
CHEMBL4176924 — IC50 = 100.0 nM 7.00
CHEMBL4175944 — IC50 = 100.0 nM 7.00
CHEMBL4160814 — IC50 = 100.0 nM 7.00
CHEMBL4165282 — IC50 = 110.0 nM 6.96
CHEMBL4164054 — IC50 = 110.0 nM 6.96
CHEMBL4176553 — IC50 = 120.0 nM 6.92
CHEMBL4161250 — IC50 = 120.0 nM 6.92
CHEMBL4169584 — IC50 = 120.0 nM 6.92
CHEMBL4164147 — IC50 = 120.0 nM 6.92
CHEMBL4173185 — IC50 = 130.0 nM 6.89
CHEMBL4175370 — IC50 = 130.0 nM 6.89
CHEMBL4161398 — IC50 = 130.0 nM 6.89
CHEMBL4172300 — IC50 = 140.0 nM 6.85
CHEMBL4171217 — IC50 = 150.0 nM 6.82
CHEMBL4177279 — IC50 = 160.0 nM 6.80
CHEMBL4161659 — IC50 = 160.0 nM 6.80
CHEMBL4174474 — IC50 = 160.0 nM 6.80
CHEMBL4172969 — IC50 = 160.0 nM 6.80
CHEMBL4176354 — IC50 = 170.0 nM 6.77
CHEMBL4168736 — IC50 = 180.0 nM 6.75
CHEMBL4166694 — IC50 = 180.0 nM 6.75
CHEMBL4167081 — IC50 = 180.0 nM 6.75
CHEMBL4175490 — IC50 = 200.0 nM 6.70
CHEMBL4171859 — IC50 = 200.0 nM 6.70
CHEMBL4168497 — IC50 = 200.0 nM 6.70
CHEMBL4168941 — IC50 = 210.0 nM 6.68
CHEMBL4174224 — IC50 = 210.0 nM 6.68
CHEMBL4164859 — IC50 = 220.0 nM 6.66
CHEMBL4173564 — IC50 = 240.0 nM 6.62
CHEMBL4161015 — IC50 = 250.0 nM 6.60
CHEMBL4161443 — IC50 = 250.0 nM 6.60
CHEMBL4163742 — IC50 = 290.0 nM 6.54
CHEMBL4168573 — IC50 = 330.0 nM 6.48
CHEMBL4173103 — IC50 = 360.0 nM 6.44
CHEMBL4161724 — IC50 = 360.0 nM 6.44
CHEMBL3091939 — IC50 = 390.0 nM 6.41
CHEMBL4172001 — IC50 = 410.0 nM 6.39
CHEMBL4174608 — IC50 = 510.0 nM 6.29
CHEMBL4166308 — IC50 = 560.0 nM 6.25
CHEMBL4171631 — IC50 = 740.0 nM 6.13
CHEMBL4167859 — IC50 = 800.0 nM 6.10