Assay Detail
Binding
CHEMBL4138365
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-fused human VEGFR2 C-terminal fragment expressed in Sf9 insect cells using poly(Glu:Tyr) 4:1 as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Quinoides and VEGFR2 TKIs influence the fate of hepatocellular carcinoma and its cancer stem cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.83 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200485 | SORAFENIB TOSYLATE | 4.0 | 1 | 8.07 |
| CHEMBL3109274 | — | — | 1 | 7.82 |
| CHEMBL4165836 | — | — | 1 | 7.75 |
| CHEMBL194176 | — | — | 1 | 7.66 |
| CHEMBL4164979 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200485 | SORAFENIB TOSYLATE | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL3109274 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4165836 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL194176 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4164979 | — | IC50 | = | 564000.0 | nM | - |