Assay Detail
Binding
CHEMBL4138488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length GST-fused human CBS using cysteine/homocysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of homocysteine and lead nitrate followed by cysteine addition
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.10 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286494 | HYPERICIN | 3.0 | 1 | 5.51 |
| CHEMBL347862 | CARBOXYMETHOXYLAMINE | — | 1 | 5.40 |
| CHEMBL4160717 | — | — | 1 | 5.23 |
| CHEMBL4167976 | — | — | 1 | 5.21 |
| CHEMBL455348 | — | — | 1 | 5.13 |
| CHEMBL4164543 | — | — | 1 | 5.11 |
| CHEMBL4172426 | — | — | 1 | 5.09 |
| CHEMBL220745 | PODOCARPUSFLAVONE A | — | 1 | 5.05 |
| CHEMBL1172216 | SIKOKIANIN C | — | 1 | 5.04 |
| CHEMBL1208973 | CUPRESSUFLAVONE | — | 1 | 4.94 |
| CHEMBL65320 | AGATHISFLAVONE | — | 1 | 4.77 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286494 | HYPERICIN | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL347862 | CARBOXYMETHOXYLAMINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4160717 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4167976 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL455348 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4164543 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4172426 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL220745 | PODOCARPUSFLAVONE A | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1172216 | SIKOKIANIN C | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1208973 | CUPRESSUFLAVONE | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL65320 | AGATHISFLAVONE | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL164 | MYRICETIN | IC50 | = | 18800.0 | nM | 4.73 |