Assay Detail
Functional
CHEMBL4138492
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Antiproliferative activity against human HT-29 cells assessed as decrease in cell viability after 24 hrs by CCK8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.64 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4167976 | — | — | 1 | 5.82 |
| CHEMBL1172216 | SIKOKIANIN C | — | 1 | 5.82 |
| CHEMBL65320 | AGATHISFLAVONE | — | 1 | 5.82 |
| CHEMBL220745 | PODOCARPUSFLAVONE A | — | 1 | 5.10 |
| CHEMBL4164543 | — | — | 1 | - |
| CHEMBL1208973 | CUPRESSUFLAVONE | — | 1 | - |
| CHEMBL347862 | CARBOXYMETHOXYLAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4167976 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1172216 | SIKOKIANIN C | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL65320 | AGATHISFLAVONE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL220745 | PODOCARPUSFLAVONE A | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4164543 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL1208973 | CUPRESSUFLAVONE | IC50 | >= | 50000.0 | nM | - |
| CHEMBL347862 | CARBOXYMETHOXYLAMINE | IC50 | = | 140000.0 | nM | - |