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Assay Detail

CHEMBL4138495

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasite activity against Plasmodium falciparum assessed as inhibition of merozoites invasion into RBC by Geimsa staining-based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antimalarial drug discovery targeting apical membrane antigen 1.
Devine SM, MacRaild CA, Norton RS, Scammells PJ.
Medchemcomm (2017) 8 : 13 -20
PubMed 30108688 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.12 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3596396 1 5.22
CHEMBL170724 1 5.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3596396 IC50 = 6000.0 nM 5.22
CHEMBL170724 IC50 = 9800.0 nM 5.01