Assay Detail
Functional
CHEMBL4138526
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Cytotoxicity against HEK293T cells expressing human wild type TSPO assessed as decrease in cell viability after 48 hrs by CellTiter blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.44 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4177167 | — | — | 1 | 4.62 |
| CHEMBL513922 | EMAPUNIL | 2.0 | 1 | 4.53 |
| CHEMBL481537 | PK-11195 | — | 1 | 4.17 |
| CHEMBL480041 | — | — | 1 | - |
| CHEMBL4161842 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4177167 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL513922 | EMAPUNIL | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL481537 | PK-11195 | IC50 | = | 67400.0 | nM | 4.17 |
| CHEMBL480041 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4161842 | — | IC50 | > | 100000.0 | nM | - |