Assay Detail
Binding
CHEMBL4138528
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Displacement of [3H]PK11195 from human wild type TSPO expressed in HEK293T cell membranes after 90 mins by scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.54 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513922 | EMAPUNIL | 2.0 | 1 | 8.19 |
| CHEMBL480041 | — | — | 1 | 7.71 |
| CHEMBL4165898 | — | — | 1 | 7.59 |
| CHEMBL481537 | PK-11195 | — | 1 | 7.54 |
| CHEMBL4173816 | — | — | 1 | 7.54 |
| CHEMBL4173118 | — | — | 1 | 7.52 |
| CHEMBL4164932 | — | — | 1 | 7.50 |
| CHEMBL4177167 | — | — | 1 | 7.50 |
| CHEMBL4169328 | — | — | 1 | 7.26 |
| CHEMBL4161842 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513922 | EMAPUNIL | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL480041 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL4165898 | — | Ki | = | 25.4 | nM | 7.59 |
| CHEMBL481537 | PK-11195 | Ki | = | 29.2 | nM | 7.54 |
| CHEMBL4173816 | — | Ki | = | 28.9 | nM | 7.54 |
| CHEMBL4173118 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL4164932 | — | Ki | = | 31.5 | nM | 7.50 |
| CHEMBL4177167 | — | Ki | = | 31.6 | nM | 7.50 |
| CHEMBL4169328 | — | Ki | = | 54.3 | nM | 7.26 |
| CHEMBL4161842 | — | Ki | = | 91.6 | nM | 7.04 |