Assay Detail
Binding
CHEMBL4138635
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Inhibition of human MAOA pre-incubated for 10 mins before p-tyramine substrate addition and measured after 10 mins by amplex red reagent-based microplate fluorescence reader analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazolobenzothiazine-based carbothioamides as new structural leads for the inhibition of monoamine oxidases: design, synthesis, <i>in vitro</i> bioevaluation and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.60 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161420 | — | — | 1 | 8.52 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.35 |
| CHEMBL4169343 | — | — | 1 | 8.00 |
| CHEMBL4174892 | — | — | 1 | 8.00 |
| CHEMBL4163558 | — | — | 1 | 6.33 |
| CHEMBL4174572 | — | — | 1 | 6.27 |
| CHEMBL4164511 | — | — | 1 | 6.01 |
| CHEMBL4159772 | — | — | 1 | 5.96 |
| CHEMBL4167004 | — | — | 1 | 5.95 |
| CHEMBL4168112 | — | — | 1 | 5.85 |
| CHEMBL4159922 | — | — | 1 | 5.75 |
| CHEMBL4174974 | — | — | 1 | 5.69 |
| CHEMBL4174656 | — | — | 1 | 5.63 |
| CHEMBL4172754 | — | — | 1 | 5.51 |
| CHEMBL4160195 | — | — | 1 | 5.46 |
| CHEMBL4167833 | — | — | 1 | 5.43 |
| CHEMBL4170413 | — | — | 1 | 5.39 |
| CHEMBL4164321 | — | — | 1 | 5.11 |
| CHEMBL4176042 | — | — | 1 | 5.09 |
| CHEMBL4168191 | — | — | 1 | 5.04 |
| CHEMBL4166659 | — | — | 1 | 5.04 |
| CHEMBL4160257 | — | — | 1 | 4.97 |
| CHEMBL4171534 | — | — | 1 | 4.57 |
| CHEMBL4171454 | — | — | 1 | 4.52 |
| CHEMBL4160919 | — | — | 1 | 4.51 |
| CHEMBL4159846 | — | — | 1 | 4.47 |
| CHEMBL4170002 | — | — | 1 | 4.19 |
| CHEMBL4167764 | — | — | 1 | 4.18 |
| CHEMBL8663 | — | — | 1 | 4.17 |
| CHEMBL4162079 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161420 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4169343 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4174892 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4163558 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4174572 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4164511 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4159772 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4167004 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4168112 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4159922 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4174974 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4174656 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4172754 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4160195 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL4167833 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL4170413 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL4164321 | — | IC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL4176042 | — | IC50 | = | 8180.0 | nM | 5.09 |
| CHEMBL4168191 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL4166659 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL4160257 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4171534 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4171454 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4160919 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL4159846 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL4170002 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL4167764 | — | IC50 | = | 65700.0 | nM | 4.18 |
| CHEMBL8663 | — | IC50 | = | 67250.0 | nM | 4.17 |
| CHEMBL4162079 | — | IC50 | = | 76200.0 | nM | 4.12 |