Assay Detail
Binding
CHEMBL4138636
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Inhibition of human MAOB pre-incubated for 10 mins before p-tyramine substrate addition and measured after 10 mins by amplex red reagent-based microplate fluorescence reader analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazolobenzothiazine-based carbothioamides as new structural leads for the inhibition of monoamine oxidases: design, synthesis, <i>in vitro</i> bioevaluation and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.71 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8663 | — | — | 1 | 7.71 |
| CHEMBL4176042 | — | — | 1 | 7.70 |
| CHEMBL4167004 | — | — | 1 | 6.96 |
| CHEMBL4160195 | — | — | 1 | 6.37 |
| CHEMBL4160257 | — | — | 1 | 6.19 |
| CHEMBL4159846 | — | — | 1 | 6.17 |
| CHEMBL4168191 | — | — | 1 | 6.12 |
| CHEMBL4167764 | — | — | 1 | 6.11 |
| CHEMBL4163558 | — | — | 1 | 5.78 |
| CHEMBL4166659 | — | — | 1 | 5.75 |
| CHEMBL4164511 | — | — | 1 | 5.62 |
| CHEMBL4171534 | — | — | 1 | 5.60 |
| CHEMBL4159922 | — | — | 1 | 5.54 |
| CHEMBL4159772 | — | — | 1 | 5.54 |
| CHEMBL4172754 | — | — | 1 | 5.52 |
| CHEMBL4169343 | — | — | 1 | 5.50 |
| CHEMBL4174974 | — | — | 1 | 5.49 |
| CHEMBL4168112 | — | — | 1 | 5.42 |
| CHEMBL4167833 | — | — | 1 | 5.38 |
| CHEMBL4170002 | — | — | 1 | 5.36 |
| CHEMBL4162079 | — | — | 1 | 5.33 |
| CHEMBL4170413 | — | — | 1 | 5.21 |
| CHEMBL4174892 | — | — | 1 | 5.21 |
| CHEMBL4174656 | — | — | 1 | 5.16 |
| CHEMBL4164321 | — | — | 1 | 4.68 |
| CHEMBL4161420 | — | — | 1 | 4.53 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8663 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL4176042 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4167004 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4160195 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4160257 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4159846 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4168191 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4167764 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4163558 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4166659 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4164511 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL4171534 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4159922 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL4159772 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL4172754 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL4169343 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL4174974 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL4168112 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL4167833 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL4170002 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL4162079 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL4170413 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL4174892 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL4174656 | — | IC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL4164321 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL4161420 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 61350.0 | nM | 4.21 |