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Assay Detail

CHEMBL4138729

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Functional
Antiproliferative activity in human IMR32 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type IMR-32
Confidence 1 — Organism
Curated By Intermediate

Target

IMR-32 (CHEMBL614585)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of (-)-kunstleramide and its derivatives.
Venkateshwarlu R, Chinnababu B, Ramulu U, Purushotham Reddy K, Damoder Reddy M, Sowjanya P, Venkateswara Rao P, Aravind S.
Medchemcomm (2017) 8 : 394 -404
PubMed 30108756 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.92 5.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67 COMBRETASTATIN A4 -1.0 1 5.24
CHEMBL4169124 1 5.08
CHEMBL4176896 1 5.03
CHEMBL4173807 1 5.03
CHEMBL43185 PIPERINE 2.0 1 4.99
CHEMBL4169037 1 4.97
CHEMBL4161285 1 4.97
CHEMBL4167103 1 4.96
CHEMBL4167210 1 4.96
CHEMBL4177317 1 4.93
CHEMBL4159856 1 4.92
CHEMBL4163221 1 4.87
CHEMBL4170506 1 4.80
CHEMBL4170944 1 4.79
CHEMBL4169034 1 4.78
CHEMBL4173944 1 4.76
CHEMBL4171542 1 4.72
CHEMBL4174983 1 4.69

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67 COMBRETASTATIN A4 IC50 = 5720.0 nM 5.24
CHEMBL4169124 IC50 = 8230.0 nM 5.08
CHEMBL4176896 IC50 = 9430.0 nM 5.03
CHEMBL4173807 IC50 = 9430.0 nM 5.03
CHEMBL43185 PIPERINE IC50 = 10190.0 nM 4.99
CHEMBL4169037 IC50 = 10790.0 nM 4.97
CHEMBL4161285 IC50 = 10790.0 nM 4.97
CHEMBL4167103 IC50 = 11020.0 nM 4.96
CHEMBL4167210 IC50 = 11060.0 nM 4.96
CHEMBL4177317 IC50 = 11860.0 nM 4.93
CHEMBL4159856 IC50 = 12010.0 nM 4.92
CHEMBL4163221 IC50 = 13410.0 nM 4.87
CHEMBL4170506 IC50 = 15660.0 nM 4.80
CHEMBL4170944 IC50 = 16090.0 nM 4.79
CHEMBL4169034 IC50 = 16590.0 nM 4.78
CHEMBL4173944 IC50 = 17350.0 nM 4.76
CHEMBL4171542 IC50 = 18870.0 nM 4.72
CHEMBL4174983 IC50 = 20360.0 nM 4.69