Assay Detail
Binding
CHEMBL4138818
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Binding affinity to 15N-labeled GST-tagged ING2 PHD finger domain (212 to 264 residues) (unknown origin) expressed in Escherichia coli Rosetta2 BL21(DE3) pLysS cells by NMR Spectroscopy method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methyllysine binding domains: Structural insight and small molecule probe development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.64 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092710 | — | — | 1 | 7.82 |
| CHEMBL4176148 | — | — | 1 | 7.79 |
| CHEMBL4168964 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092710 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL4176148 | — | Kd | = | 16.2 | nM | 7.79 |
| CHEMBL4168964 | — | Kd | = | 50.0 | nM | 7.30 |