Assay Detail
Functional
CHEMBL4138943
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Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.19 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168556 | — | — | 1 | 6.80 |
| CHEMBL19980 | BREFELDIN A | — | 1 | 6.80 |
| CHEMBL4160995 | — | — | 1 | 6.75 |
| CHEMBL4176423 | — | — | 1 | 6.66 |
| CHEMBL4163294 | — | — | 1 | 6.64 |
| CHEMBL4169636 | — | — | 1 | 6.64 |
| CHEMBL4171197 | — | — | 1 | 6.55 |
| CHEMBL4168173 | — | — | 1 | 6.55 |
| CHEMBL4160256 | — | — | 1 | 6.52 |
| CHEMBL4175050 | — | — | 1 | 6.40 |
| CHEMBL4171606 | — | — | 1 | 6.34 |
| CHEMBL4171906 | — | — | 1 | 6.21 |
| CHEMBL4159923 | — | — | 1 | 6.10 |
| CHEMBL4164398 | — | — | 1 | 6.07 |
| CHEMBL4164731 | — | — | 1 | 6.04 |
| CHEMBL4161312 | — | — | 1 | 5.92 |
| CHEMBL4175353 | — | — | 1 | 5.80 |
| CHEMBL4161707 | — | — | 1 | 5.36 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.31 |
| CHEMBL4167834 | — | — | 1 | 5.24 |
| CHEMBL114717 | — | — | 1 | 5.20 |
| CHEMBL3810201 | — | — | 1 | - |
| CHEMBL4169038 | — | — | 1 | - |
| CHEMBL4176903 | — | — | 1 | - |
| CHEMBL4177300 | — | — | 1 | - |
| CHEMBL4166672 | — | — | 1 | - |
| CHEMBL4162170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168556 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL19980 | BREFELDIN A | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4160995 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4176423 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4163294 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4169636 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4171197 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4168173 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4160256 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4175050 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4171606 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4171906 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4159923 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4164398 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4164731 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4161312 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4175353 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4161707 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4167834 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL114717 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3810201 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4169038 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4176903 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4177300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4166672 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162170 | — | IC50 | > | 10000.0 | nM | - |