Assay Detail
Functional
CHEMBL4138944
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Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.00 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168556 | — | — | 1 | 6.75 |
| CHEMBL19980 | BREFELDIN A | — | 1 | 6.46 |
| CHEMBL4171906 | — | — | 1 | 6.42 |
| CHEMBL4171197 | — | — | 1 | 6.39 |
| CHEMBL4163294 | — | — | 1 | 6.29 |
| CHEMBL4176423 | — | — | 1 | 6.29 |
| CHEMBL4168173 | — | — | 1 | 6.27 |
| CHEMBL4169636 | — | — | 1 | 6.26 |
| CHEMBL4164398 | — | — | 1 | 6.21 |
| CHEMBL4160256 | — | — | 1 | 6.21 |
| CHEMBL4159923 | — | — | 1 | 6.14 |
| CHEMBL4175353 | — | — | 1 | 6.12 |
| CHEMBL4175050 | — | — | 1 | 6.09 |
| CHEMBL4160995 | — | — | 1 | 6.09 |
| CHEMBL4161312 | — | — | 1 | 6.08 |
| CHEMBL4171606 | — | — | 1 | 6.04 |
| CHEMBL4164731 | — | — | 1 | 5.89 |
| CHEMBL114717 | — | — | 1 | 5.80 |
| CHEMBL4167834 | — | — | 1 | 5.75 |
| CHEMBL4161707 | — | — | 1 | 5.40 |
| CHEMBL4169038 | — | — | 1 | 5.40 |
| CHEMBL4176903 | — | — | 1 | 5.19 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.54 |
| CHEMBL3810201 | — | — | 1 | - |
| CHEMBL4177300 | — | — | 1 | - |
| CHEMBL4166672 | — | — | 1 | - |
| CHEMBL4162170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168556 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL19980 | BREFELDIN A | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4171906 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4171197 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4163294 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4176423 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4168173 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4169636 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4164398 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4160256 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4159923 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4175353 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4175050 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4160995 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4161312 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4171606 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4164731 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL114717 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4167834 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4161707 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4169038 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4176903 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3810201 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4177300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4166672 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162170 | — | IC50 | > | 10000.0 | nM | - |