Assay Detail
ADMET
CHEMBL4138945
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Cytotoxicity against human L02 cells assessed as reduction in cell viability after 72 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.03 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163294 | — | — | 1 | 5.30 |
| CHEMBL4171197 | — | — | 1 | 5.29 |
| CHEMBL4171906 | — | — | 1 | 5.29 |
| CHEMBL4160995 | — | — | 1 | 5.29 |
| CHEMBL4171606 | — | — | 1 | 5.28 |
| CHEMBL4160256 | — | — | 1 | 5.27 |
| CHEMBL4175050 | — | — | 1 | 5.24 |
| CHEMBL4176423 | — | — | 1 | 5.23 |
| CHEMBL4168173 | — | — | 1 | 5.23 |
| CHEMBL4164398 | — | — | 1 | 5.23 |
| CHEMBL4168556 | — | — | 1 | 5.22 |
| CHEMBL4169636 | — | — | 1 | 5.21 |
| CHEMBL4167834 | — | — | 1 | 5.17 |
| CHEMBL4175353 | — | — | 1 | 5.17 |
| CHEMBL4159923 | — | — | 1 | 5.16 |
| CHEMBL4161312 | — | — | 1 | 5.14 |
| CHEMBL4164731 | — | — | 1 | 5.11 |
| CHEMBL114717 | — | — | 1 | 5.02 |
| CHEMBL4161707 | — | — | 1 | 5.01 |
| CHEMBL4176903 | — | — | 1 | 4.54 |
| CHEMBL4169038 | — | — | 1 | 4.50 |
| CHEMBL4177300 | — | — | 1 | 4.46 |
| CHEMBL3810201 | — | — | 1 | 4.44 |
| CHEMBL4166672 | — | — | 1 | 4.43 |
| CHEMBL4162170 | — | — | 1 | 4.40 |
| CHEMBL19980 | BREFELDIN A | — | 1 | - |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163294 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4171197 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4171906 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4160995 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4171606 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4160256 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4175050 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4176423 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4168173 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4164398 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4168556 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4169636 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4167834 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4175353 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4159923 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4161312 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4164731 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL114717 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4161707 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4176903 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4169038 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4177300 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3810201 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4166672 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4162170 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL19980 | BREFELDIN A | IC50 | < | 0.4 | nM | - |
| CHEMBL185 | FLUOROURACIL | IC50 | - | — | - |