Assay Detail
Functional
CHEMBL4139092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell survival after 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of bis(indolyl)ketohydrazide-hydrazones: Identification of potent and selective novel tubulin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.04 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49642 | INDIBULIN | 2.0 | 1 | 7.13 |
| CHEMBL4177045 | — | — | 1 | 6.30 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.26 |
| CHEMBL4163131 | — | — | 1 | 5.77 |
| CHEMBL4160462 | — | — | 1 | 5.54 |
| CHEMBL4167590 | — | — | 1 | 5.25 |
| CHEMBL4165355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49642 | INDIBULIN | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4177045 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4163131 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4160462 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4167590 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4165355 | — | IC50 | - | — | - |