Assay Detail
Binding
CHEMBL4139300
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Reversible competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured over 5 mins by Dixon plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.45 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168617 | — | — | 1 | 5.80 |
| CHEMBL462946 | DISCORHABDIN B | — | 1 | 5.72 |
| CHEMBL4160694 | — | — | 1 | 5.46 |
| CHEMBL553245 | DISCORHABDIN L | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168617 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL462946 | DISCORHABDIN B | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL4160694 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL553245 | DISCORHABDIN L | Ki | = | 15000.0 | nM | 4.82 |