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Assay Detail

CHEMBL4139303

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AChE
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
Botić T, Defant A, Zanini P, Žužek MC, Frangež R, Janussen D, Kersken D, Knez Ž, Mancini I, Sepčić K.
Eur J Med Chem (2017) 136 : 294 -304
PubMed 28505534 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.60 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL659 GALANTAMINE 4.0 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL659 GALANTAMINE IC50 = 250.0 nM 6.60