Assay Detail
Binding
CHEMBL4139382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]muscimol from human GABAA receptor alpha1beta3gamma2 expressed in HEK293 TetR cell membranes after 1 hr by liquid scintillation counting method
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
GABA-A receptor; alpha-1/beta-3/gamma-2 (CHEMBL2094121) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.35 | 6.60 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163464 | — | — | 2 | 6.60 |
| CHEMBL190279 | ALFAXALONE | 2.0 | 2 | 6.35 |
| CHEMBL4174166 | — | — | 2 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163464 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL190279 | ALFAXALONE | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4174166 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4174166 | — | Inhibition | - | % | - | |
| CHEMBL4163464 | — | Inhibition | - | % | - | |
| CHEMBL190279 | ALFAXALONE | Inhibition | - | % | - |