Assay Detail
Functional
CHEMBL4139731
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Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RBC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.55 | 7.77 |
| Ki | 5 | 8.78 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513681 | — | — | 1 | 9.10 |
| CHEMBL4160732 | — | — | 1 | 8.98 |
| CHEMBL4175851 | — | — | 1 | 8.88 |
| CHEMBL4175454 | — | — | 1 | 8.74 |
| CHEMBL404168 | — | — | 1 | 8.22 |
| CHEMBL4168653 | — | — | 1 | 7.77 |
| CHEMBL4165135 | — | — | 1 | 7.63 |
| CHEMBL273807 | — | — | 1 | 7.63 |
| CHEMBL4167064 | — | — | 1 | 7.46 |
| CHEMBL4163380 | — | — | 1 | 7.46 |
| CHEMBL4173768 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513681 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL4160732 | — | Ki | = | 1.047 | nM | 8.98 |
| CHEMBL4175851 | — | Ki | = | 1.318 | nM | 8.88 |
| CHEMBL4175454 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL404168 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL4168653 | — | EC50 | = | 16.98 | nM | 7.77 |
| CHEMBL4165135 | — | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL273807 | — | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL4167064 | — | EC50 | = | 34.67 | nM | 7.46 |
| CHEMBL4163380 | — | EC50 | = | 34.67 | nM | 7.46 |
| CHEMBL4173768 | — | EC50 | = | 46.77 | nM | 7.33 |